"Skittles - A Benefit to Herself" a beautifully written story by a wonderful dog owner!

This is an example of Dr. Plechner's heart and practice that stems for his love for animals and their owners! Please read this triumphant story if you wonder about the quality of life for your pet and what you can do to improve their health or to make the right decision for your pet! http://www.jesusjazzbuddhism.org/she-is-a-benefit-to-herself-the-value-of-being-alive.html

Dr. John R. Lee, M.D. - Medical Newsletter with insights from experts in the Endocrinology field

Dr. Lee was an endocrinologist and published "Medical Letters" for years. In his 2003 letter he lists experts in his field and below is the excerpt he published from Dr. Plechner. To read more of Dr. Lee's letters and research, please Google "The John R. Lee, M.D. Medical Letter - Insights, Opinions, News and Reviews from John Lee and Friends." EXPERTS IN THE FIELD IS YOUR PET'S HEALTH SUFFERING? It Could be Unrecognized Hormonal Imbalances By Alfred J. Plechner, D.V.M. In thousands of cases spanning three decades, I have identified an unrecognized hormonal syndrome that weakens the immune system and promotes sickness and premature death in dogs and cats. Because of this widespread and unsuspected disorder, veterinarians are seeing an increase in the following: Cancer Autoimmune diseases Relentless skin allergies Severe hypersensitivity to food and insect bites Chronic bacterial, viral, and fungal infections Deadly feline viruses Inflammatory bowel disease Vaccination complications Obesity Miscarriages and sterility Chronic health problems among younger animals In most cases, I am able to help patients—even very sick ones—regain health by correcting the hormonal disturbances and thus restore effectiveness to the immune system. The complete therapeutic program brings veterinarians and pet owners together to do the necessary testing, treatment and home care. The problem originates with genetic or acquired damage (such as from toxicity or stress) to the adrenal glands, where the hormone cortisol is produced. A domino effect is unleashed. Hormones go awry. Estrogen is overproduced. Thyroid function is impaired. Immune cells become deregulated and dysfunctional. I consistently see this cortisol-based pattern in sick patients. In fact, every cancer patient I treat has it. Cortisol is an extremely important hormone. At a healthy basic level it exerts a major anti-inflammatory effect, a property that inspired the development of cortisone (synthetic cortisol) drugs more than a half-century ago. At a normal level, it also exerts a discriminating regulatory effect on molecular agents that turn on or turn off activity related to immunity. A deficiency or defect in cortisol may result in an unresponsive immune system just as too much of it suppresses immune responses. Most of my sick patients have a shortage of good, working cortisol. I believe the problem stems in large part from modern breeding practices that emphasize fashionable appearance and devalue hardiness and function. These practices create flawed, designer pets ridden with genetic defects. The endocrine-immune syndrome I have found is among many defects, however it has not been widely recognized. Moreover, the defect is no longer limited to purebred pets. Mating between breeds has thoroughly spread the imbalances. Cortisol is a cornerstone of the HPA axis, a classic hormonal “feedback loop” that involves the hypothalamus, pituitary and adrenal glands. Scientists now recognize that this axis has central importance to immune function, however they still lack a clear understanding of the countless details and interactions. A shortage of cortisol causes the pituitary to constantly secrete a substance called adrenocorticotropic hormone (ACTH). Usually, the adrenal gland responds by producing more cortisol. However, if the gland cannot meet the demand, or the cortisol is somehow ineffective or excessively bound, the flow of ACTH will also stimulate the release of estrogen compounds. This appears to happen in all imbalanced animals, including males and spayed females, so it’s not an ovarian estrogen issue. Rather it seems to stem from direct production of estrogens by the adrenal glands or from androstenedione, a masculine hormone that can convert to the estrogen compound estrone, which in term converts to the more “potent” estrogen estradiol. How Cortisol Dysfunction Affects Our Pets This scenario of low cortisol and elevated estrogen has major trouble-making potential. Here’s a few of the disturbances it can cause: Destabilization of B and T cell activity, primary components of the immune system, and thus loss of normal disease protection. Impairment of thyroid function by binding thyroid hormones, and interfering with normal transference of T4 to active T3, and the cellular uptake of T3. This has the potential to slow down metabolic processes. Increased inflammation. Inflammation in the intestinal tract, for instance, may interfere with absorption of nutrients and medication. In the uterus, inflammation may undermine the normal conception process. Unexpected sexual behavior. Spayed females mounting other females, or neutered males humping other males, are not uncommon sights. Cortisol-based imbalances can trigger an excess of estrogen and also testosterone that may promote residual sexuality even though the animals are fixed. Unfortunately, pet owners can’t test for and resolve the imbalances on their own. They need an open-minded veterinarian willing to follow a procedure that he or she didn’t learn in veterinary school or from a textbook. I hope one day that the endocrine-immune syndrome I have found will be covered in veterinary textbooks, but at this point it is not. I personally consult with a number of veterinarians who use my program (you can find a list on my web site,www.drplechner.com). When veterinarians and pet owners follow this endocrine-immune balance program they report results just as gratifying as I achieve in my clinic. The details for the program are spelled out in my new book, and consist of three major elements: 1) A special endocrine-immune blood test. The test measures cortisol, total estrogen, thyroid hormones (T3 and T4) and the following antibodies: IgA, IgG and IgM. Testing routinely reveals a similar pattern of low cortisol, elevated estrogen, bound thyroid hormones, and low antibodies in sick animals whether they are males or females, intact or neutered. To do the test, veterinarians perform a simple blood draw and send the blood in a cold pack to one of several major veterinary testing laboratories. Intact females should not be tested when in estrus. The results of the test can be interpreted by consulting the information contained in my book. If imbalances are present, the patient is retested after two or three weeks into the therapy program to determine if modification of treatment is needed. 2) Long-term therapy using low-dosage steroid medications, and for most dogs, thyroid medication (T4 only). Pharmaceutical derivatives of cortisol—that is, cortisone (steroid) compounds—have become prominent mainstream medicines because of their clinically important anti-inflammatory and immune suppression applications. Over the years we have learned a great deal about the side effects of these compounds when used at typically powerful, pharmacologic dosages. For that reason steroids are usually prescribed for the short term and avoided for prolonged use. This development has discouraged interest in the pivotal roles of cortisol and applications of low-dosage cortisone as a “hormone replacement” for cortisol deficiency. In my program I use cortisone medications—either a natural hydrocortisone (derived from soy) or a pharmaceutical such as Vetalog or Medrol—not to suppress symptoms, as these preparations are conventionally used for, but to replace a lack of active cortisol. I use only enough medication to normalize estrogen, thyroid, and the immune system. Used in this conservative manner, there are beneficial, healing effects and no side effects. William Jefferies, M.D., of the University of Virginia, has used low-dosage steroid medication safely and effectively for decades to help patients with chronic allergies, autoimmune disorders and chronic fatigue. My therapy also calls for additional thyroid medication (T4 only) for most dogs. Due to some species variation, most cats don’t require the additional thyroid medication. Those with a condition called feline infectious peritonitis do need thyroid. Pet owners usually must administer medication on a daily basis. In general, improvement on the program is rapid and animals stay healthy as long as the therapy is followed. 3) A careful diet that eliminates food allergens. The one thing that can upset the therapy and improved health is food! Animals with food allergies all have endocrine-immune imbalances, and even when the imbalances are corrected they can still react to food to which they are individually sensitive. Thus, pets need to be on hypoallergenic diets that are rotated every few months to avoid problems. Convenient hypoallergenic diets can be purchased through veterinarians or pet stores but caregivers still need to be alert. Each animal is individual and can be sensitive to even the most wholesome of foods or the worst of chemical additives. Even severely diseased animals make great comebacks on the program, living long and high-quality lives. For more details, and the practical how-to information, I suggest obtaining a copy of my new book Pets at Risk (NewSage Press, www.newsagepress.com), available through book sellers the middle of October.

STRESS and Adrenal Dysfunction

This article articulates the effects of stress on humans and animals as it relates to Adrenal Dysfunction. Written by Jonathan Collin, MD promotes Dr. Plechner's research and theory in this article: http://www.townsendletter.com/Dec2008/ltrpub1208.htm

SARDS - Emmi 8 yr old Golden Retriever

My precious Golden Retriever, Emmi is 8 years old. She was diagnosed with SARDS early this year. The veterinarians told me that she was completely blind and that there was no hope. A serendipitous conversation with the kind people from Halosforpaws steered me in Dr. Plechner's direction. I spoke to him and, with the cooperation of Emmi's vet, Dr. Debbie Bear, we started Emmi on his prescribed program. To say that this has changed her life would be an understatement! Not only has she regained her zest for life but she's actually regained some of her sight! Dr. Plechner has taken control of Emmi's care from the first time I've spoken with him, without any compensation for his time or knowledge! While I respect the perspective that Skept Vet has brought forward (there are certainly a lot of quacks in the medical field!), I have to temper that respect with the knowledge that, from the very beginning, Dr. Plechner has asked NOTHING of me! He's phoned me at least a dozen times, he's emailed me, he's spoken with Emmi's vet, and has asked for nothing in return! If he's a quack I think Skept Vet needs to come up with some new parameters to determine the definition of a quack! I think we can all agree that, with the increase in allergies, auto immune diseases, cancer, etc., something has changed in the world. Until someone can explain it, and back it up with research, I'm willing to listen to people who can produce results. I have a healthy, happy dog. Dr. Plechner is the reason! I haven't paid him a cent! He's not only made a believer out of me, he's managed to convince Emmi's vet, and she's no rookie either! I'm not a religious person, but I thank God, for whatever transpired to put me in touch with this amazing man! I'm not a wealthy man, but money can't buy what I've learned from this experience. Dr. Plechner is a great vet, but he's even a greater man! Thank you Al!

Wade Church Just before Christmas, Emmi's owner, Wade, took a video of Emmi following his hand with a treat and moving her head side to side. Something she was unable to do two months prior. Feb 1, 2014, Wade reported that Emmi continues to improve and do well with treatment. They went to the mountains over the weekend and enjoyed some hiking.

Montmorillonite Clay - Earth's Living Clay

How Living Clay Can Help Your Pet Live Better By Dr. Al Plechner, DVM Contents Scientific Facts about Clay ....................................................................................................................... 3 Types of Clay ......................................................................................................................................... 3 How Clay Works .................................................................................................................................... 4 Trace Minerals Revisited ........................................................................................................................... 5 How Clay May Help ............................................................................................................................... 7 Clay for Pets ............................................................................................................................................... 7 Treating Renal Disease ......................................................................................................................... 7 Promote Better Health for Horses...................................................................................................... 11 Mineral Supplements May Be the Answer to Skin Problems ........................................................ 12 How Calcium Montmorillonite Clay Can Help Avians ..................................................................... 15 The Need for a Calcium-Balanced Diet in Cats ............................................................................... 15 How to Care and Feed for Pregnant Dogs and Cats ...................................................................... 17 Suggested Clay Protocol ..................................................................................................................... 18 Summary .................................................................................................................................................. 20 Disclaimer: The information herein is intended for informational purposes only. The statements contained herein have not been evaluated nor approved by the US Food and Drug Administration, AMA, or any other US government agency. Any dietary changes and/or product(s) mentioned should not be used to diagnose, treat, cure, or prevent any disease. Always consult your healthcare professional before making any changes to your health care regimen (especially if you are taking medications, are pregnant, trying to get pregnant, nursing, or if you have any other compromised health condition) before making any dietary changes, using any products mentioned, or applying any information contained herein. Page 3 of 21 Scientific Facts about Clay There are many types of clay that perform different functions making it very important to choose one that will fit your needs as well as the needs of your pets. Bentonite is a generic term that refers to a mineral compound that typically has one predominant mineral, typically either calcium or sodium. The focus of this chapter is on calcium bentonite clay. Calcium bentonite clay - also known as living clay - has both internal and external medical uses, as well as uses in industry. All references here pertain to clay as a natural remedy for health and wellness. The name Montmorillonite clay originates from the original clay deposit found in Montmorillon, France, which was exhausted years ago. Today, Montmorillonite is used to describe certain properties – including the clay structure – found in certain clays. There are mixed opinions among the scientific world as to the use of living clays, however most of the scientific community agrees on the following:  Clay minerals all contain oxygen, silicon, potassium and other trace minerals.  The actual clay structure will determine the use of a particular clay  Montmorillonite clay is the clay of choice for internal and external medical use. Types of Clay There are many different types of clay, each with variations in shapes, sizes and mineral composition. In fact, the mineral structure of a clay determines its specific properties. All clay deposits have different mineral structures. Some are naturally fine and pure. Some deposits are shallow and having been exposed to the environment, contaminated with toxins and other impurities. Some clays are sun-dried while others are irradiated or washed with alcohol or otherwise treated. Such practices greatly diminish the effectiveness of the ionic properties of the clay. All bentonite clay contains a percentage of minerals in addition to calcium as well as a percentage of sand and silt. The process of removing the sand and silt from the clay takes time and adds to the cost, but it produces a higher quality product. In addition to the many types of clay available, there is also much misinformation about clay. With the advent of the Internet, anyone can hang a shingle and sell products. Consider the following questions when buying clay:  Is the clay specifically intended for internal use by humans?  Is the clay sedimentary or from volcanic ash?  Is the predominant mineral (after silica dioxide) calcium or sodium? Page 4 of 21  Has the clay been tested for pathogens by an independent laboratory and is a copy of the results available to consumers?  Is a mineral analysis available to consumers?  Is there a phone number to call and talk to an actual person about the clay?  Does the supplier have positive reviews and testimonials?  Has the clay been chemically treated or irradiated?  Is the packaging professional and not home-made?  Does the vendor have a professional website in addition to selling on amazon, craigslist, etsy and the like? Since we’re talking about your pet’s health and wellness, it’s better to be safe than sorry! How Clay Works Calcium Montmorillonite clay contains one of the strongest negative ions of all the edible clays available today. This negative ionic charge not only enhances the availability for absorption of foods, vitamins, supplements and glucose but also increases their ability to go through the cell wall into the factory of the cell, which is called mitochondria. This allows the mitochondria to produce more energy and more oxygen for use in the body. Negatively-charged ions can enhance our immune defenses, reduce susceptibility to colds and the flu as well as provide relief from migraine headaches, allergies and hay fever. Positive ions such as those found in polluted air – of which there are many more in today’s environment than in times past – create an electrical imbalance in the atmosphere and in our bodies. Positive ions are also known as free radicals. Free radicals can damage cells and are thought to be responsible for degenerative health conditions, accelerated aging and even cancer. Positive ions are what comprise toxins, impurities, viruses and pollutants. Negative ions are beneficial because of their ability to attract and stick to different positive ions or free radicals. This is what makes bentonite clay such a powerful detoxifier. Calcium bentonite clay is highly charged with negative ions and looks to attract positive ions to it when ‘activated’. Adsorption and Absorption As the body does not absorb the clay, it is perfectly safe to consume. However not all clays available are intended for internal use. Be sure to ask the supplier if the clay being offered is considered safe for internal consumption. When mixed with food or water and taken internally, clay is eliminated through normal digestive and perspiration processes. Adsorption refers to the process through which substances stick to the exterior of the clay structure. It is here on the surface of the clay structure where the ionic exchange Page 5 of 21 between the clay and the toxins and other impure substances take place. This is a key part of clay’s ability to detoxify. Absorption is a more familiar concept to most of us. It refers to the ability of the clay to act like a sponge and draw toxins and impurities from its environment. Absorptive clays expand to accommodate this process and are also known as expandable or swelling clays. This ability to swell provides calcium bentonite clay with greater drawing or detoxifying ability. Clay and Radiation Bentonite clay was used in the Chernobyl nuclear disaster to absorb the deadly levels of radiation caused by the nuclear reactor melt down. The reactors were smothered with bentonite clay due to its well-known ability to absorb and adsorb positively-charged ions. Bentonite clay neutralizes radiation. The more recent Fukushima nuclear disaster in Japan continues to present major environmental problems. Migratory fish in the Pacific Ocean have been exposed to major levels of radiation. Now, not only is there a fear of eating fish that are high on the food chain that may contain higher amounts of mercury, but now radiation has also become a factor. Warnings to not consume fish from these waters are not without merit. More and more people living on the West coast of North America are consuming bentonite clay as a precautionary measure against radiation in food, water and air. Chelation The importance of these trace minerals - in addition to providing micronutrients that do not occur in depleted agricultural soils - is that they have been created in a chelated state, meaning that the body will not absorb any of these micronutrients unless the body needs them. This eliminates the possibility of over- mineralization. Trace Minerals Revisited It has been more than 25 years since I wrote about my findings around trace minerals in Pet Age magazine. Ever since that time, I have realized that micronutrients play a tremendous roll in the development of modern day diseases. This really is the tip of the "iceberg" as to identifying the medical diseases we are seeing today, caused by deficient nutrients that no longer come to ourselves or to our animals in the foods we eat and the foods we feed them. Micronutrient deficiencies are causing worldwide diseases in people and animals. Page 6 of 21 Scientific evidence is mounting that genetically modified (GM) foods are harmful to human health over an extend period of time. Unfortunately, our beloved pets do not have the long lifespans that humans have. This means that conditions – good or bad – that impact human health are going to do so much more quickly than it would in people. This makes the impact of GMOs on our pets even more devastating. It’s vital to be vigilant in avoiding GMO foods and treats for your pets. Plants grown from genetically modified seeds render the soil in which they’re grown micronutrient-deficient. As a toxin, clay can play a vital role in removing GMOs from the body. The value of micronutrients not only lies in their presence in food and making sure the patient does is not deficient, but also in their ability to help other vitamins, nutrients and supplements enter through the cell membrane. This occurs due to the negative ion these chelated micronutrients contain. Without them, many of the products that are ingested or produced in the body never get through the cell membrane to enhance the production of energy and oxygen for the body to use to help fight off disease. Since exploring the use of micronutrients in the late 70's and early 80's, a remarkable amount of wonderful academic research has been completed on this natural, hydrothermally trace mineral, created by the earth. Dr. Benjamin H. Ershoff, while working for Cal Tech, demonstrated to N.A.S.A. Manned Space Center, that bone density loss ( known as osteoporosis), that occurs with prolonged walks in space at zero gravity does not happen if the astronauts ingest this clay routinely. This special, natural clay, not only reversed the effects of bone loss, but stopped it from happening. Other scientific investigations have been done by Dr. Paul A. La Chance. Using this clay in male rats, hamsters, mice, miniature pigs, kangaroos and other mammals, he proved that normalization and recalcification of bone density occurred. Why not apply this same clay to millions of people and animals that suffer from many types of bone density loss or an inability to absorb other forms of calcium. This special calcium Montmorillonite clay has high levels of calcium in a form that is chelated. This means that in this chelated form, the body will absorb only what the body needs. Dr. Howard E. Lind has completed a number of successful studies showing the anti- bacterial effects of this special calcium Montmorillonite clay including its ability to neutralize toxins. These are very important for people and animals that are sensitive to certain antibiotics. At the same time, the product will help neutralize toxins that may occur in our foods or the foods we feed our animals that already contain toxic food ingredients from foreign countries. Patients suffering from acid reflux and or IBS (irritable bowel syndrome) receive relief due to the high level of chelated calcium. Page 7 of 21 How Clay May Help In my profession it is believed that the use of a calcium supplements in a large breed puppy may create excess bone growth with a bone malady being the end result. This will not happen with calcium bentonite clay, as the chelated calcium will only be used *if* the puppies bone growth dictates it. Bone loss is very common with people and animals with chronic kidney disease. The kidney disease often retains phosphorus and the body tries to maintain a 1:1 or 1:2 ratio between calcium and phosphorus and to do this, the body removes the calcium from the bones and ligaments. The high level calcium contained in this micronutrient product will help stop this. In allied species, it has been scientifically proven in research facilities in Asia, that this special calcium Montmorillonite clay does cause elevated blood urea to be concentrated out of the blood, into the intestines for excretion. Supplementation with this special living clay may make a difference for the patient, while providing an additional natural supplement to enhance their nutritional health and aid the actual healing process. We can only treat the clinical effects of a disease, but often the success or failure of our therapy will depend on the overall health of the patient. Calcium Montmorillonite can make that difference. Clay for Pets The information here is intended to help concerned pet owners understand some of the ways this amazing gift from the earth may help their beloved pets. It’s not unreasonable to believe that if clay is used to successfully treat a given condition in one type of animal (including people!) that it will also be effective treating the same condition in another type of animal. For this reason, I recommend reading through ALL sections of this chapter in order to understand the many issues that can be helped with clay. Treating Renal Disease Introduction Both acute and chronic kidney failure are serious illnesses that afflict dogs, cats, horses and other animals. Conventional treatment can help manage many of the symptoms. Supplementing with calcium Montmorillonite clay may help with a number of conditions brought on by kidney failure. Scientific research has proven calcium Montmorillonite effective in preventing osteoporosis and there are virtually no contraindications for its use. In addition to augmenting standard treatment for kidney disease, calcium Montmorillonite clay can be used as a daily supplement for animals to improve overall health. Page 8 of 21 What is Kidney Disease? Kidney disease in dogs and cats often occurs in two main groups. 1. Acute Kidney Failure The first group relates to a sudden failure of the kidneys known as acute kidney failure. This generally occurs when the patient ingests a poison or a toxin or is exposed to Leptospirosis (a rare and serious bacterial infection) and through urine formation, the kidneys are damaged. 2. Chronic Renal/Kidney Failure The second group relates to a slow deterioration of the functional units of the kidneys. In cats, this condition is referred to as chronic renal failure. In dogs, this condition is referred to as chronic kidney failure. This can happen through slow ingestion of toxins, damaging heavy metals, poisons, radiation, and chronic inflammation due to an infection or due to an endocrine immune imbalance. Improper diet, and/or a diet containing poor quality protein may also cause an excess use of the kidneys’ ability to breakdown and excrete increased amount of nitrogenous waste products. Often the patient loses muscle mass, overall weight, and loss of appetite due to the elevated nitrogen level. Once your health care professional has made this diagnosis - and with your help - the following treatments may be suggested. Conventional Treatments Subcutaneous or intravenous fluids may be instigated to help perfuse the kidneys and help flush out the nitrogenous waste products. Note: If this is done for 48 hours, and the very elevated BUN diminishes only 10 to 15 points, there is a good chance that the kidneys may be permanently damaged, and to continue therapy may cause unnecessary suffering and expense for the patient. Your health care professional will advise you properly. A special diet is usually recommended. For many years, a low protein diet was recommended, as it is thought to reduce the “pressure” placed upon the remaining functional kidney units referred to as nephrons for protein breakdown. The kidneys both in animals and humans detox waste product from the process of metabolizing protein. I have always believed, that high quality protein, in a small quantity, more frequently, would allow for less insult on the remaining nephrons. For pets, this would include the same attributes sought for humans:  Organic  Grass-fed  Hormone- and antibiotic-free Page 9 of 21 The diet also needs to be low in phosphorus since with kidney failure, phosphorus retention occurs. Often Omega 3 fatty acids are given and their anti-inflammatory action can be enhanced when Vitamin E is also given, to help reduce any inflammation that is helping destroy the kidneys. Much more recently krill oil is being substituted for the fatty acids. A product called Calcitriol is often given due to advanced kidney disease, which may cause a lack of Vitamin D production. Tumil K (potassium gluconate) may be needed, if the kidney disease causes the potassium levels to drop too low. A Natural, Complementary Treatment Health care professionals and pet owners that would like to use a more natural treatment to not only enhance normal treatment of patients with kidney disease, but also as a preventative treatment to help reduce the development of kidney disease, should consider including the use of calcium Montmorillonite clay. I have found this to be a better way to enhance the treatment of kidney disease in both dogs and cats even while still using traditional therapy. As I am not an equine veterinarian I cannot report on my direct experience of patients’ use of clay to treat renal disease in horses, but I assume it is similarly effective. Improved Micronutrient Absorption Calcium Montmorillonite clay from the Death Valley area in California originates from volcanic ash that has baked in the hot sun for many centuries. It is thought that the exposure to high temperature from the sun, allows the micronutrient to lose one molecule of water, and create a negative ion that allows the micronutrient – once ingested - to enter the cell, through the cell membrane. This negative ion helps other essential nutrients, vitamins and supplements to traverse the cell membrane also. Detoxification Another important feature of this special calcium Montmorillonite is that it helps neutralize harmful toxins that enter the body through the mouth, the nose and the skin. When hydrated, the clay’s negative ionic charge becomes available. As it moves through the body, the clay attracts positively charged molecules (toxins, most parasites, harmful bacteria, allergens) to the outside surface of the clay molecule. In addition, the clay absorbs or binds the toxins into its internal molecular structure. The negative ions are exchanged with the positive ions and the clay is eliminated from the body. Conditions Clay May Improve Page 10 of 21 Elevated Nitrogen The elevated nitrogen that builds up in the blood stream from failing kidneys can cause many problems. The resulting high level blood urea nitrogen (BUN) can irritate the mucous membranes of the stomach and intestines, reduce red blood cell production and inflame the pancreas. Often Carafate is used to sooth this irritation. Calcium Montmorillonite contains many micronutrients, which will have a similar soothing effect like Carafate, but is natural. Gastrointestinal Irritation The irritation of the gastrointestinal system that occurs from the elevated BUN can cause nausea, vomiting and diarrhea and the calcium Montmorillonite will help stop this with its soothing effect. Calcium Montmorillonite aids with absorption of normal foods while also “settling” the stomach and intestines. Mineral Imbalance Calcium Montmorillonite also provides chelated potassium and calcium to help correct any ratio imbalance caused by failing kidneys. Osteoporosis From Phosphorous Retention Another serious problem that is often encountered with kidney disease in animals is the retention of phosphorus. The body tries to maintain a 1:1 or 1:2 ratio of calcium to phosphorus. When kidney disease causes retention of phosphorus, the body often will remove calcium from the bone in order to try to maintain a normal ratio, causing osteoporosis. Products like Amphogel and Maalox are used to help keep the phosphorus levels under control. Including the use of a calcium Montmorillonite, which is very high in chelated calcium, and can make a difference in reducing the amount of bone loss that occurs due to the kidney retention of phosphorus. It is also used extensively in people and animals that suffer from lack of bone density, aka osteoporosis, that do not have kidney disease. Scientists and researchers have found that the use of calcium Montmorillonite will allow for normal bone density to remain, while also correcting a state of diminished bone density. Bacterial Infections Not only can the use of calcium Montmorillonite help stop bacterial infections in the already damaged kidneys, but it can also help neutralize toxic molecules that may continue the damage. Page 11 of 21 Elevated Urea Renal studies in allied species conducted at X’an Jiaotong University College of Medicine indicate that calcium Montmorillonite will help reduce elevated serum urea through concentration and increased excretion by the intestines. Clay Protocol For more information on how to use clay for your pet, see the protocol for clay use at the end of this chapter. Promote Better Health for Horses Calcium Montmorillonite clay will aid in promoting maximum health for both you and your horse and will also promote better healing from many diseases, when included with standard, medical therapy. Calcium Montmorillonite clay promotes healthy bones, ligaments, and tendons, while stopping bone loss, referred to as osteoporosis. N.A.S.A. has used this product for several years, to help stop bone loss in the astronauts as a result of time spent in space at zero gravity. Clay is not only important for all horses, but is especially important for pregnant mares. Over the years, calcium Montmorillonite clay has improved fertility, promoted easier birthing and much healthier offspring, with a much higher survival rate in horses and all allied species. It is best to use clay daily, even before fertilization of the mare occurs, and continued during and after the pregnancy. In the maturing embryo, a good quality, naturally chelated calcium is of tremendous importance, to produce stronger bones, ligaments and tendons for her foal at birth. The efficiency and the amount of the chelated calcium found in calcium Montmorillonite, not only will help the mare maintain her bone density while being pregnant, but also will help increase her milk production when her foal is born. This is vital to newborn foals and helps stop the creation of a weak, decalcified skeletal system, which may lead to bone malformation and early crippling. Proper calcification is also vital in those horses competing in different types of athletics events. Calcium Montmorillonite clay neutralizes toxins and provides a protective antibacterial action, and does help to reduce the major health problems that come from feed contamination. For the best results, include clay in your horse’s food or water every day. Calcium Montmorillonite clay will definitely help the liver – the primary organ of detoxification - to neutralize toxins and give the liver a chance to heal itself. Calcium Montmorillonite clay also contains a naturally, chelated kaolin, that helps sooth the intestines and reduce the risk of colic. Page 12 of 21 If the dose of the clay is doubled, often a fluid return is created in the intestines, which often helps soften impactions, while also providing antibacterial and antitoxin action against some of the bowel inhabitants that produce an increase in gas, which can contribute to a horse’s discomfort. Research studies show that intestinal parasites flourish in a normal intestinal pH of 6 to 6.5. There are reports that indicate that calcium Montmorillonite clay – many with a pH as high as 9.7 – raises that pH significantly. In this environment, intestinal parasites can no longer live and are shed naturally. The calcium Montmorillonite clay can be mixed with water and used as a healing paste, and applied twice daily to skin infections, bacterial eruptions, wire cuts, abrasions and insect bites. Clay Protocol For more information on how to use clay for your horse, see the protocol for clay use at the end of this chapter. Mineral Supplements May Be the Answer to Skin Problems Mention nutrition to most people and they automatically think of vitamins. However, they really ignore the role of minerals. Minerals really deserve more attention. After all, there are 96 times more minerals, by weight, in a body than vitamins. There could be no life without them and cells lacking in a single mineral cannot function optimally. Minerals are present in soil, in water, and even in air, and help minute vitamins to form enzymes. They help transport oxygen into the bloodstream. They are the building materials of strong bones, tissue, teeth, nails and the hair coat. Minerals are present in the soil, in water and even in air. In minute amounts they are absorbed from the soil by plants. As herbivores eat plants and drink water, they obtain the bulk of their mineral nutrients. Carnivores get their quota through the mineral content of the flesh they eat, the water they drink and the sporadic greens they chew. Much more is known about vitamin requirements than about mineral needs. This is true for both humans and animals. That's because nutritional science only recently has developed the technology with which to study minerals. Veterinary science has determined that certain minerals are required for animals. For cats, the vital minerals are calcium, phosphorus, sodium, potassium, magnesium, iron copper and iodine. Chlorine, manganese, zinc, sulfur, cobalt, selenium, molybdenum, fluorine, chromium, silicon and perhaps tin, nickel and vanadium are also assumed to be essential. For dogs, mineral needs include calcium, phosphorus, iron, copper, potassium, magnesium, sodium, chlorine, iodine, manganese, zinc, selenium, and perhaps molybdenum, fluorine, tin, silicon, cobalt, nickel, vanadium and chromium. Page 13 of 21 Such minerals should be included in the minimum standards for the maintenance of adequate health. If a product claims to be "complete and balanced", the suggested serving for an animal must meet all daily minimum requirements. It is important to keep the word "minimum" in mind at all times. The Required Daily Amount suggestion and "complete and balanced" claims are nothing more than minimal requirements. They are not optimal in any sense. We haven't evolved so far as food mavens to design the best possible food diet for our animals. Look how poorly we do for our own nutritional needs! Veterinary science is doing its best, but has a long way to go. Supplements In my practice, I have used both vitamins and mineral supplementation as methods for preventing skin problems and aiding in therapeutic programs. By far my best success has been with the use of minerals rather than vitamins. Generally speaking, I do not find allergic skin conditions to be very responsive to vitamins. In fact, I have found supplementation with B - complex vitamins frequently causing the allergy to become worse because yeast is used as the most common commercial sources of natural B vitamins, and yeast is a leading allergen. Using minerals, I have experienced consistently good results. I believe this may relate to inadequate mineral levels in commercial pet foods. A deficiency of minerals has been involved in at least 10 % of all allergy cases I have treated. The pet food industry might lack knowledge as to what constitutes good mineral levels for daily animal needs. Also, depletion of minerals in the soil is a problem. According to a 1981 Ford Foundation report on nutrition in America, modern farming methods alone account for much lost nutritional content of food. "Through intensive farming, poor crop management, increasing use of pesticides, erosion and other abusive factors, the soil in which are crops are raised has been seriously depleted of nutrients." Such practices rob the food chain of naturally-occurring essential vitamins and minerals. Thus the food you and your animal eat is "short- changed". Illness from these deficiencies can range from subtle to catastrophic. Over the years, veterinarians have linked deficiency diseases with a wide number of minerals. These include deficiencies in nitrogen, phosphorus, calcium, potassium, magnesium, sodium, iron, chlorine, copper, manganese, zinc, molybdenum, cobalt, iodine and selenium. Mineral research is a dynamic, rapidly developing science. Sophisticated techniques are being honed to probe the biological roll of "trace minerals" (also known as micronutrients), present in infinitesimal amounts in the environment. These include Page 14 of 21 dozens of lesser-known minerals with exotic names as yttrium, niobium, ruthenium, tellurium, scandium, osmium, dysprosium, gadolinium and praseodymium. Any of these unheralded elements could be a vital missing link in deficient soils and may mean the difference between good health and disease, even at one part per million or less. The body's immune system is a particularly complex network that relies on optimal nutrition for good function. If all the ingredients are not present, the system will not work as well. A shortage of minerals can affect the body's enzyme systems, which are responsible for countless numbers of biochemical reactions. Allergy or allergy-like conditions can occur when either of these systems does not receive proper nutrition. Mineral deficiencies may be involved with many common disorders suffered by dogs and cats. I did not reach this conclusion through sophisticated scientific analysis or advanced technology but rather through the simple medium of supplementing the diets of animals with a trace mineral formula containing all the essential micronutrients. Results Based upon observations involving approximately 3,700 dogs and 900 cats, I found the trace mineral compound added to their food or water over a six-month period, the skin and hair coat of these animals showed the following:  Darker, thicker hair coat, with increased luster.  Reduced itching and scratching.  Reduced flaky skin.  In geriatric dogs and cats, increased activity, weight gain and improved condition of the hair coat.  Animals with heavy flea and fly infestations appear less attractive to insects after three weeks of supplementation.  Increased fertility and more viable offspring  Improvement in overall general health. In quite a few cases, vitamin supplements, special diets and standard medication did not work satisfactorily until I included trace minerals. On the other hand, I have found the trace mineral approach effective alone or in conjunction with other dietary modifications. It also enhances standard therapy while treating many conditions. Supplementation with a trace mineral nutrient of the sort found in calcium Montmorillonite clay is clearly a "shot gun" approach. In dogs, mineral supplements have been helpful in controlling food allergies, flea-allergy dermatitis, exocrine pancreatic deficiency (digestive enzyme deficiencies), endocrine immune imbalances, chronic active hepatitis and inhalant allergies. In cats, it has helped control milliary dermatitis, food allergies, flea allergy dermatitis, chronic active hepatitis, leukemia and feline infectious peritonitis. Clay Protocol Page 15 of 21 For more information on how to use clay for your pet, see the protocol for clay use at the end of this chapter. How Calcium Montmorillonite Clay Can Help Avians I have had the opportunity to use this natural compound as an additive to enhance the health of many birds, including chickens. I had a bird of prey center set up for the US Wildlife Service plus the Department of Fish and Game in the State of California, in the Santa Monica Mountains for many years. This included the treatment of many other native wild birds and mammals. My preserve was called Stone Wood Meadows and was located at the base of Cold Canyon in the hills of Malibu. Cold Creek runs through the property and also provided 10,000 acres of habitant release. Stone Wood Meadows set a coastal standard for wildlife over recreation in the coastal zone in California. As a veterinary student graduating from The University of California at Davis, I took several classes in avian medicine. My clinical studies, using calcium Montmorillonite clay demonstrated the following:  Higher egg shell thickness  Improved egg production  Less infant mortality  Better absorption of nutrients. This owes to the negative ion effect that takes the nutrients, vitamin and supplements directly through the cell wall to the mitochondria for increased energy and increased oxygen.  Binding numerous toxins that all birds may be exposed to when free ranging.  Better control of bacterial infections due to its desiccating properties. This also helps with organically raised birds which are not subjected to synthetic antibiotics in their food and water.  Reduction of feather picking  Visible increases in feather production and color. My other recommendation is that genetically modified seeds are never used for feed, as these are themselves toxic to the system. The Need for a Calcium-Balanced Diet in Cats Whether large or small, domestic or wild, felines need a balanced diet including proper amounts of calcium to avoid developing thin bones with the possibility of pathological fractures. Over the years, my research has proven that the ratio of calcium to phosphorus is vital in a feline as well as *all* animals (including people) in order to maintain a healthy Page 16 of 21 skeletal system and avoid unnecessary incidental fractures due to a calcium phosphorus imbalance causing thin bones. It was realized a number of years ago, that zoo-fed felines given meat only (without bones and skin) developed thin bones. The result was that after jumping from a small height, they would fracture their front legs. In the wild this did not happen. In the wild, felines ate most of their prey including bones and skin which contain calcium and the meat only which contained one part calcium to 20 parts phosphorus. If only meat is given or eaten, the body of the feline tries to keep a 1:1 or 1:2 ratio between calcium and phosphorus. As the feline ingests the total meat diet, the body tries to keep the proper calcium phosphorous ratio. It does this by removing calcium from the bones causing the thinning and weakening of the bones that lead to the incidental fractures referred to as pathological fractures. This abnormal ratio causes the parathyroid gland to release its hormone which in turn causes this calcium bone depletion. Senior Project at University of California Davis While in veterinary school, my senior project found me working with a young mountain lion in Oakland, California. He was a 4 month old, male named, Tigger. Whenever he jumped off an object - even a low chair or mattress - he would fracture the bones in his front legs, referred to as pathological fractures. This was due to the fact that the cortices of his long bones were tissue thin, along with all the other bones in his body. It was the general opinion that he was suffering from osteogenesis imperfect, which in humans, is a genetic disorder that leads to the same kind of pathological fractures as seen in Tigger. After analyzing Tigger's diet, I found he was being fed a total meat (no bones or skin), diet, which has 20 parts of phosphorus to 1 part calcium. He definitely did *not* have osteogenesis imperfecta, but rather a serious nutritional imbalance. Tigger’s daily total meat diet with its 20 to 1 ratio of phosphorus to calcium was his true nemesis. His body knew it needed to keep a 1:1 or 1:2 ratio between phosphorus and calcium. To do so, his body was forced to remove calcium from his bones, because of the excess release of PTH (parathyroid hormone). In doing so, his bones became very weak and fractured on their own. Upon realizing this, I had the pet owner add calcium and bones to his diet and in the weeks that followed, the recalcification of his skeletal system occurred. As he felt better, when petting him, he would purr and it sounded like a motor boat. Just to see the look in his eyes now, seemed to justify all his pain and suffering that was now over. And you know what - he knew it. My paper detailed how his disorder was not, in fact, ostoegenesis imperfecta but rather a nutritional hyperparathyroidism. A few years later it was realized that all the big cats in Page 17 of 21 the zoos and other captive sites also needed to be fed bones with their meat to avoid similar problems. I am pleased with the fact that, after I created my first commercial non-meat, balanced food product for dogs and cats with calcium and phosphorus, it too was adopted for use in zoos. Clay Protocol For more information on how to use clay for your pet, see the protocol for clay use at the end of this chapter. How to Care and Feed for Pregnant Dogs and Cats Once you and your veterinarian have decided your dog or cat is at least 5 weeks pregnant, it is best to offer a third meal at lunch time if your pet is interested. I personally believe it is best to keep protein, carbohydrate and fat in the same ratio. It is important to increase the nutrition for your pet while pregnant, but not to increase their weight. The increased amount of foods is designed to help her embryos develop to their maximum. At this same time a calcium, magnesium compound, including a Montmorillonite clay, should be given twice daily and continued two weeks past weaning. This will help guarantee that the mother does not develop low blood calcium, which may lead to excessive shaking and seizures. This is typically found in dogs with large litters, whether the mother is small or large. If the litter is fairly large, it is best to place the puppies and kittens into two separate groups, which will allow them to nurse at separate times thus avoiding a loss of nutrition to one or more of the offspring. Did you know that 90% of the deaths that occur with normal offspring come from lack of nutrition and reduced body temperature? A proper bed for mom and her offspring is also very important. Unless provided for, it is a known fact that certain large breeds mistakenly lie on their offspring, which can result in death of the babies. Once the puppies and kittens have reached 2 to 2 ½ weeks of age, it is best to start offering the offspring baby meats, quickly followed by baby meats mixed with canned food. Allowing the offspring to nurse after they reach 3 weeks of age, may be very damaging to their mother and her overall health. Please remember, 48 hours post-delivery, the offspring on mother's milk cannot absorb the antibodies in the milk known as colostrum. While you are beginning solid food for the offspring, if the mother's breasts continue to fill up with milk, it may be necessary for the pet owner to either milk the glands or allow for short term nursing or have your veterinarian give the mother an injection to dry up the milk. Page 18 of 21 If this is your pet's first litter, it is always a good idea to speak to your veterinarian for directions. I personally like to do an x-ray at 6 ½ weeks of the pregnancy, to check for the size of the pelvic outlet as compared to the size of the heads of her offspring. Also it is important to know approximately how many offspring are present for delivery, and if the offspring are in the normal position for delivery. Using Calcium Montmorillonite Clay A pregnant female must eat a food that will allow her to provide maximum nutrition not only for herself, but also for her unborn offspring, while in-utero. Many people add fresh foods and nutrients to the diet to hopefully provide a complete and better quality food. But is this really enough? What few of us realize is that we are still facing the perils of the soil. Many of today’s available food sources are grown in agriculturally overworked soils. Considering this in combination with the overuse of petrochemical and synthetic fertilizers, it surprises me that many litters appear to be normal at birth. Micronutrients help fund so many different biological systems in our bodies and the bodies of animals. When there is a deficiency in any one micronutrient, all of our species can suffer from many different diseases including infertility, low sperm count, a reduced size of the litter and even early resorption and/or early loss of part or all of the entire litter. Calcium Montmorillonite clay has been tested and proven to contain all the necessary micronutrients that may be deficient in our foods that are grown in overworked agricultural soils. Because these micronutrients occur in a chelated form, the body will only absorb what the body needs. This stops the possibility of hyper mineralization from occurring. It is very safe to give this natural product to very large, pregnant dog breeds without the fear of causing increased, abnormal bone growth in the puppies. This is because the fast-growing puppies - whether in the uterus or outside of mom - will only absorb the amount of chelated calcium that their normal bone growth requires. Many times, when a dog is pregnant, they can be nauseated and that causes a reduction the amount of food they eat which in turn can reduce the nutrition going to the puppies in the uterus. That in turn can lead to a weak or reduced litter or even a total loss of the litter. Many times I have found that naturally chelated clay would soothe her gut and she would eat more food. Suggested Clay Protocol Page 19 of 21 The following suggestions are based on my 40+ year clinical experience. However, you and your veterinarian need to decide what protocol to follow. Clay can be added to drinking water or to wet food. Internal Use - Cats and Dogs Adding to Drinking Water When adding to water, mix clay 1 part clay to 8 parts water in a food grade plastic or glass bottle. Shake well. Fill half the water dish with clay water and half with fresh water. Clay will settle over time. Top water off each day for 2 or 3 days and start fresh on the fourth day. Be sure water dish is glass or ceramic. Plastic is an option, but since plastic is porous, bacteria from the animal’s mouth can penetrate the surface and become in itself somewhat toxic. Adding to Wet Food Cats in particular need lots of water for good health. Try having a water dish with clear, fresh water and another of clay water available. Animals instinctively know when their body needs support and they will choose whichever they feel they need. Add dry clay on a daily basis to wet food according to the animal’s body weight. Body Weight Dry Clay to Add < 20 pounds ½ tsp. 20 – 50 pounds 1 tsp. 50 – 90 pounds 2 tsp. > 90 pounds 1 Tbsp. As with people, be sure to have plenty of water available for drinking. Internal Use - Horses  Foals should receive one heaping tablespoon sprinkled on their food AM and PM.  Adult horses should receive two heaping tablespoons sprinkled on their food AM and PM.  Most foods that are fed to horses happen to be dry so a small amount of water can be sprayed on the food before the clay is sprinkled on the food.  Pregnant mares should receive three heaping tablespoons AM and PM.  Horses suffering from various diseases should receive three to four heaping tablespoons AM and PM.  To reduce bacterial build up and toxins and add clay to the horse’s water supply, at a ratio of one cup of dry clay to every 50 gallons of water. External Use – All Animals Page 20 of 21 Poultice Create a clay poultice by combining one part clay to three parts clean water. Stir to a sour cream-like consistency. Allow to stand for 12 to 24 hours to thicken. Apply the poultice directly on skin lesions, hot spots, wounds, bites and sores twice daily for 7 days and beyond as needed, until the skin has healed. Keeping the clay damp keeps the clay working. If feasible, apply a damp paper towel or damp gauze on top of the poultice. If needed, cover with a plastic bag of plastic wrap. Clay Baths For animals with skin and coat issues that are not conducive to clay poultices, clay baths may help ease irritation and itching. Mange and other parasitic infections can also be addressed with clay baths. Medium to Large Dogs Pour the tub ¼ to ½ full with clean, warm water. Add 1 cup dry clay and mix into bath water. Place animal in the tub and coat the skin with bath water. Work the water well into the coat, saturating it with clay water. Repeat for 10 to 20 minutes or as long as the animal will tolerate it and the water stays warm. Rinse the coat with clean water and towel or air dry. Small Dogs and Cats Pour the tub or sink ¼ to ½ full with clean, warm water. Add ¼ to ½ cup Add 1 cup dry clay and mix into bath water. Place animal in the tub and coat the skin with bath water. Work the water well into the coat, saturating it with clay water. Repeat for 10 to 20 minutes or as long as the animal will tolerate it and the water stays warm. Rinse the coat with clean water and towel or air dry. Summary What many people in the world are coming to realize is that the foods we and our pets eat and the environments we live in are exposing both ourselves and our pets to a myriad of toxins, heavy metals and radiation. The negative impact on our health ranges from merely irritating to chronic disease. It has been proven and documented that calcium Montmorillonite clay will not only bind toxins and heavy metals but will also neutralize radiation. The wonderful natural properties of a calcium Montmorillonite clay can make a huge difference for our families and our pets. Over 35 years ago I began using calcium Montmorillonite extensively in my practice to treat many different conditions as well as for better overall health for all of my patients including dogs, cats, horses, livestock, birds, wildlife and fish. I recommend daily Page 21 of 21 supplementation of pet food with calcium Montmorillonite to help reduce the effects of toxins, damaging heavy metals and radiation. I have also used it successfully with my friends and family, our family pets and of course - myself. Dr. Al Plechner, DVM, is a practicing veterinarian in Los Angeles and the author of several books. He works with pet owners that want to achieve optimal health, maximize their longevity and create a healthy future for themselves and their beloved pets. Dr. Plechner makes his homes in Santa Monica, California and Orofino, Idaho. Learn more about Dr. Plechner at www.drplechner.com. © Dr. Al Plechner, DVM 2013 | www.drplechner.com

Detoxification

I ask Dr. Plechner about everything. I ask him about anything to do with medical, veterinarian, general health and nutrition, as well as the latest fads I read about in the media. He answers everything and here is his take on Detoxification in relation to humans and dogs: "I am sure there are various toxins that everyone can be exposed to that will effect a serious change in the hormone regulation of the immune system which I believe causes allergy, autoimmunity and cancer. However there are also genetic defects in the hormone regulation of the immune system, and when exposure to various toxins occur, they can even make these imbalances considerably worse. Shasta is a patient that has hormone antibody imbalances and normalizing her endocrine immune system will help her body detoxify normally. I have used the montmorillinite clay for many years with myself, my family and my patients, because it detoxes damaging heavy metals and damaging toxins either from the environment and also man made. It also neutralizes radiation while supplying micronutrients that no longer occur in our soils do to being overworked agriculturally. Doing a calcium bentonite with montmorillinite will do almost everything you need to do with Shasta to detoxify her along with correcting her endocrine immune imbalance. Many of the clinical symptoms in people and the clinical signs found in animals, can come from allergies etc. and sometimes the detoxification process can not only be very damaging, but very dangerous for the patient to experience. I would rather be careful with my foods, chemical and radiation exposures and take Clay." To read more about montmorillinite clay, please see my post titled "Montmorillinite Clay."

Raw Food Diet

Dr. Karen Becker, DVM is an advocate of the raw food diet and she explains why in easy to understand details in these three videos... http://www.youtube.com/watch?v=Qx2YIIpF4cc http://www.youtube.com/watch?v=TJPToVsJj-c http://www.youtube.com/watch?v=Pn1F7AsmEkw Dr. Becker explains why raw food is easier for dogs to digest and it makes sense why dogs with low IgA levels or malabsorption do better on the raw food diet. Rather than asking your general vet about the raw food diet, because they will suggest Science Diet, Iams, and probably Royal Canin, go to your local dog food specialty store and ask them what they feed their dogs and why! The right dog food is THE KEY to pet health and although expensive, it will decrease your vet bills!

Shasta's EI-1 blood panel results

Here is will I show the results of Shasta's EI-1 Blood Panel results with the dates so you can see her progression: EI-1 Lab Results Normal Range Results from 8/13/13 Results from 9/10/13 Results from 10/10/13 Results from 1/31/14 Cortisol 1.00-2.50 1.97 1.59 0.88 1.09 T3 100.00-200.00 86.24 82.05 126.84 124.16 T4 2.00-4.50 1.66 1.43 3.36 3.14 Total Estrogen 30.00-35.00 35.13 35.1 35.09 35.05 IgA 70-170 57 60 61 65 IgM 100-200 77 84 87 94 IgG 1,000-2,000 784 836 868 938 Dr. Plechner's interpretation of the results: increase to 15mgs of Medrol per day and should see more improvement.

Phytoestrogens

Phytoestrogens: Phytoestrogens are substances found in plants (phyto-) that have estrogen-like properties. Phytoesterogens latch onto the receptor sites on cells meant for estrogen. This results in a partial stimulation of those receptors, less intense than if true estrogen had attached, but stronger than if nothing had stimulated those receptors at all. This leads to a dual result. In women who have considerable estrogen, high consumption of phytoestrogens tends to occupy the receptor sites and keep real estrogen away. The net effect is to reduce the overall action of estrogen. Since estrogen promotes a number of forms of cancer (such as breast cancer), this may reduce cancer risk. However, in women who have little estrogen (after menopause, for example), consumption of large amounts of phytoestrogens will tend to mimic the effect of the missing estrogen, reducing symptoms such as hot flashes. Phytoestrogens are found in numerous foods, most prominently soybeans (and many other types of beans), red clover, flaxseed, and whole grains. The phytoestrogens found in these foods include isoflavones and lignans. 1 Herbs with high phytoestrogen content include alfalfa , hops , licorice , thyme, and verbena. 1,2 Certain herbs that are often claimed to contain phytoestrogens actually do not. These include wild yam , saw palmetto , and chasteberry . Dong quai , ginseng , and black cohosh do not appear to contain phytoestrogens in the ordinary sense, but might contain substances that mimic some of the actions of estrogen under certain circumstances. Here is a list of of foods and drinks with the calculated amount of phytoestrogens found in each. Please note this list is not comprehensive and there are other foods such as carrots and apples in which phytoestrogens are found to contain, but I could not find any material that lists the amounts: Flax seed 379380 Soy beans 103920 Soy nuts 68730.8 Tofu 27150.1 Tempeh 18307.9 Miso paste 11197.3 Soy yogurt 10275 Soy protein powder 8840.7 Sesame seed 8008.1 Flax bread 7540 Multigrain bread 4798.7 Soy milk 2957.2 Hummus 993 Garlic 603.6 Mung bean sprouts 495.1 Dried apricots 444.5 Alfalfa sprouts 441.4 Pistachios 382.5 Dried dates 329.5 Sunflower seed 216 Chestnuts 210.2 Olive oil 180.7 Almonds 131.1 Cashews 121.9 Green bean 105.8 Peanuts 34.5 Onion 32 Blueberry 17.5 Corn 9 Coffee, regular 6.3 Watermelon 2.9 Milk, cow 1.2 Soy bean sprouts 789.6 Garlic 603.6 Winter squash 113.7 Green beans 105.8 Collards 101.3 Broccoli 94.1 Cabbage 80 Fruits   Dried prunes 183.5 Peaches 64.5 Strawberry 51.6 Raspberry 47.6 Watermelon 2.9 Nuts and other legume seeds Pistachios 382.5 Chestnuts 210.2 Walnuts 139.5 Cashews 121.9 Hazel nuts 107.5 Lentils 36.5 Beverages Wine, red 53.9 Tea, green 13 Wine, white 12.7 Tea, black 8.9 Coffee, decaf 5.5 Beer 2.7 Other   Black bean souce 5330.3 Black licorice 862.7 Bread, rye 146.3

Xenoestrogens

Xenoestrogens have been implicated in a variety of medical problems, and during the last 10 years many scientific studies have found hard evidence of adverse effects on HUMAN and ANIMAL health. Xenoestrogens may temporarily or permanently alter the feedback loops in the brain, pituitary, gonads, and thyroid by mimicking the effects of estrogen and triggering their specific receptors or they may bind to hormone receptors and block the action of natural hormones. Here are two articles that explain the implications of xenoestrogens and provide a list: http://voices.yahoo.com/what-xenoestrogens-they-affect-your-12004093.html> http://endojourney.wordpress.com/2009/07/31/a-list-of-xenoestrogens/>

The Plechner Syndrome and Protocol

Plechner's Theory Another advocate of Plechner's theory is Patricia Pepper, who shares a pet success story with SARDS, explains it this way..."What Dr. Plechner did was find that a major regulating hormone–cortisol, which according to the world expert for cortisone, medical school professor, William Jeffries is the ONLY hormone ESSENTIAL for life– is deficient or bound in many animals and that this situation sets up further hormonal imbalances, specifically the binding of thyroid hormone often by the creation of reverse t-3, the generation of excess TOTAL estrogens in the system due to pituitary hyper-stimulation which occurs to the lack of functioning active cortisol, and that these hormonal imbalances deregulate the immune surveillance. He found that by putting back the amount of cortisone which replaces the missing active cortisol and by replacing bound thyroid hormone the immune surveillance can be regained. This is why the Plechner treatment protocol has been found to be so effective against feline retroviruses." "Dr. Plechner figured out how to determine the amount of cortisone to put back into the system but looking at the pituitary gland by a testing protocol that measures the TOTAL estrogen which occurs under hyper stimulation of the adrenals by the pituitary. When there is not enough ACTIVE, unbound cortisone in the system. By doing lots of lab testing–originally out of his own pocket, Dr. Plechner noted the relationship between the endocrine system and the immune system–that when the missing hormones were supplied in the dose that satisfied the pituitary by stopping the pituitary hyper stimulation of the adrenals, the B cell and T cell populations that he followed in his laboratory testing, normalized." "Now after fifty years and a hundred thousand animals and hundreds of thousands of lab tests, it is seems that this entirely logical therapy which rebalances a major command system in the biochemistry–which insures the adequate supply of the only hormone which is absolutely essential for life, and which also insures an adequate supply of a hormone–thyroid hormone–which is essential for optimal oxygen metabolism, which is the sine e qua non of the mammalian biochemistry–has been thoroughly demonstrated to be of enormous value in the art of Medicine. In fact, it is the establishment which has been remiss in not making further studies of what Dr. Plechner has discovered."

Adrenal Related Illnesses

Definitions and terminology of Adrenal Imbalances Cushing's disease. A rather severe overactivity of hyperfunction of the glands. Characteristics are obesity in the trunk area, muscle weakness, poor wound healing, and kidney stones. This condition is relatively rare and usually caused by a tumor of the adrenal glands that secretes cortisol or cortisone, two of the important adrenal hormones. It could be caused by a tumor in the pituitary gland, or perhaps in the hypothalamus. Addison's disease. A type of extremely low adrenal activity is known as Addison’s disease.   It is characterized by weakness, fatigue, low blood pressure, changes in skin color, dehydration, anorexia, nausea, decreased cold tolerance and dizziness.   It is also considered a fairly rare condition.             Addison’s disease could also be caused at times by a tumor on the adrenal glands that shuts down the glands completely.   It may also be caused by a severe shock to the system, as happened in the famous case of president John F. Kennedy. Pasted from Adrenal insufficiency. It's been observed that in many cases, the adrenal glands themselves are toxic and nutritionally depleted. Other times the cause stems from an autonomic nervous system imbalance. Dr. Lawrence Wilson, MD published an article on Adrenal Burnout Syndrome in The Center For Development, August 2012. His theories are based on human adrenal conditions, but his findings are interesting and relatable to animals nonetheless. Dr. Wilson uses a hair analyses rather than blood, urine, or saliva tests to determine depletion patterns in minerals such as sodium, potassium, calcium and magnesium. He states than when humans have lower than ideal values of minerals adrenal exhaustion, or burnout, occurs. These patterns help determine the patient's oxidation type, oxidation rate, tendency for inflammation and infection, deficiencies of important minerals. He then designs a program to slowly rebalance the body chemistry to restore health. It is believed by alternative medical doctors that the causes of adrenal exhaustion are excessive stress, chemical toxicity, nutritional deficiency, and poor genetics. Diets low in protein contribute to these deficiencies, excessive carbohydrates can stress the adrenals and poor quality water affects oxygenation. Our food today is grown in depleted soils and processing further depletes nutritional value in our foods. Low cortisol symptoms include low blood pressure, low blood sugar, depression, and allergies. Copper toxicity and burnout can stem from elevated copper and low zinc which will impair the immune system and chronic infections can develop; this sets the stage for more severe illnesses such as cancer and heart disease to occur. Hyperthyroidism can occur as well. Cortisol provides a natural "high" while low cortisol levels contribute to feelings of depression. When the adrenal glands are weak, copper builds up in the body and can cause a slew of mental disorders such as bipolar disorder...as energy levels deplete other toxic metals build up like mercury, lead, cadmium, arsenic and others. Dr. Wilson's suggested recovery program for humans is a diet of cooked vegetables and animal protein, drinking only distilled or spring water, lots of rest, basic nutritional supplements based on his interpreted hair mineral analysis, and a detoxification protocol. http://www.drlwilson.com/articles/adrenal_burnout.htm After reading about adrenal exhaustion theories among humans, it is even more clear to me how real this illness is in humans and animals. So many practitioners treat the symptoms of an illness instead of getting the to crux of the issue.

Adrenal Exhaustion

The adrenal glands are your body’s primary "shock absorbers." These two little thumb-sized glands sitting on top of your kidneys produce hormones including norepinephrine, cortisol and DHEA that allow you to respond to the conditions of your daily life in healthy and flexible ways. Norepinephrine (also called adrenaline) is commonly thought of as the fight-or-flight hormone. It’s produced when something is (or you think it is) threatening. This hormone makes your heart pound, your blood rush to your heart and large muscle groups, your pupils widen, your brain sharpen, and your tolerance for pain increase—basically, it prepares you for battle. Modern-day battles are most likely things like pushing your body to keep going when it’s fatigued, dealing with a stressful job, and reacting with quick reflexes to avoid a traffic accident. Think of these adrenaline surges as withdrawals from a bank, to help you get through life’s rough spots. If you have gotten into the habit of withdrawing adrenaline from your account too often, you’ll eventually be overdrawn and your adrenal glands will be overwhelmed. Then, you’ll have too little adrenaline when you really need it. Reference: Adrenal exhaustion: the adrenal glands become exhausted and no not function properly resulting in production of inadequate quantities of hormones. It is said that millions of people are affected by this syndrome, yet conventional medicine still does not consider it a real illness. However, a significant proportion of alternative medicine practitioners are confident it exists. Conventional health care professionals do not accept "adrenal exhaustion" as a proper diagnosis, but they do recognize other forms of adrenal dysfunction, such as Addison's or adrenal gland insufficiency. Some symptoms of adrenal exhaustion: Lethargy Insatiable appetite Low blood pressure Suppressed immune system (having difficulty recuperating from illnesses) Abrupt weight loss Allergies Muscle weakness According to alternative health practitioners, this syndrome is caused by toxic chemical pollutants over a period of time, excessive amounts of stress burdening the body for a long-term period, and/or malnutrition. The adrenal glands sit on top of the kidneys and are made up of the outer adrenal cortex and the inner medulla, both of which produce hormones. The adrenal cortex is made up of three layers, each responsible for secreting distinct hormones. The outer layer is the main site for aldosterone production, which is largely responsible for regulating blood pressure and balancing sodium and potassium levels. The middle layer is responsible for producing cortisol which is responsible for the mobilization of fats, proteins, and carbohydrates. It also enhances activity of other hormones. It secretes a basal level of cortisol, but can also produce bursts of the hormone in response to adrenocorticotropic hormone (ACTH) from the anterior pituitary. The inner layer produces androgens such as dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione (the precursor to testosterone) and estrogen hormones. The thyroid gland and the adrenals have a very close relationship and stress on one always affects the other. Reference: A damaged middle layer of the adrenal cortex causes a reduction in active (working) cortisol, resulting in an elevated amount of estrogen to be produced by the inner layer adrenal cortex. Normal amounts of cortisol may be present, however this cortisol can be defective or bound and the same estrogenic effect may occur. The cortisol and estrogen imbalance usually presents itself as an altered immunity status with antibody depression present. This not only may result in malabsorption from the intestines, but also allows the immune cells to lose recognition of the body's own tissue and thus attack their own host. These changes in glandular performance allow for a variety of medical effects to occur anywhere from allergies, irritable bowel disease, autoimmunity, uncontrolled tissue growth, and cancer. Addison's Syndrome - involves the FIRST LAYER of the adrenal cortex where the hormone ALDOSTERONE is produced, which balances Sodium and Potassium levels. (which is not only responsible for electrolyte balance, but works with a hormone from the kidney to regulate blood pressure). Cushing's Syndrome -involves the MIDDLE LAYER adrenal cortex where the hormone CORTISOL is produced which is necessary for life. CUSHING'S SYNDROME is the production of too much active (working) cortisol. ESTROGEN is a hormone that is part of a group of estrogenic compounds. With normal amounts of ESTROGEN production present, this hormone helps to develop female secondary sex characteristics in the animal. This hormone can be produced by the ovaries, THE INNER LAYER OF THE ADRENAL CORTEX, testes and placenta. Other forms of ESTROGEN can also be ingested from fruits, vegetables and plastics. Imbalanced CORTISOL allows for the pituitary gland to over-stimulate the production of excess ESTROGEN. This excess estrogen not only causes an inflammation of the lining cells of all arteries in the body, including those arteries to the intestines, but causes the B and T immune cells to become deregulated. It also causes the B cell to reduce its production of antibodies. This in turn causes further turmoil in the gut. When regulated, the B cell protects the body against bacteria and makes protective antibodies to vaccines and other intruders. When the T cell is regulated it protects the body against viruses and plant invaders like yeast and fungi. The hormonal antibody deregulation is why all of these intruders can cause medical effects (illnesses and diseases). when there is an excess of estrogen being produced (or present), it may also cause the following: A chemical binding of both thyroid hormones (T3 and T4). A chemical binding of active (working) CORTISOL and this in turn disallows or prevents the transference of storage thyroid (T4) into active thyroid (T3) in the body. The deregulation of the immune system which causes it not only to be unable to PROTECT the body, but to further lose recognition of self tissue and thus be able to DESTROY the normal tissues in the body. It also causes the immune system to decrease antibody production for protection and from creating protective antibodies from natural invaders and vaccines. It also can lead to an inflammation of the cells lining all the arteries in the body (ENDOTHELIAL CELLS). Inflammation of the arteries may lead to not only strokes and heart attacks, but also to any disease that might respond to a decreased blood flow and lack of proper oxygenation. When we see excess estrogen and defective or insufficient cortisol we also see: Reduced numbers of specific immunoglobulins, such as IgA. Frequent clinical symptoms of autoimmune disease. Reduced IgA levels in serum. Immunoglobulins: IgA, IgM, and IgG in particular are tested for and closely monitored. Immunoglobulin A (IgA) is an antibody that plays a critical role in mucosal immunity. More IgA is produced in mucosal linings than all other types of antibody combined;[1] between three and five grams are secreted into the intestinal lumen each day.[2] This accumulates up to 15% of the total immunoglobulin produced in the entire body.[3] IgA has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA). In its secretory form, IgA is the main immunoglobulin found in mucous secretions, including tears, saliva, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in blood. The secretory component of sIgA protects the immunoglobulin from being degraded by proteolytic enzymes, thus sIgA can survive in the harsh gastrointestinal tract environment and provide protection against microbes that multiply in body secretions.[4] sIgA can also inhibit inflammatory effects of other immunoglobulins.[5] IgA is a poor activator of the complement system, and opsonises only weakly. Its heavy chains are of the type α. IF IgA is BELOE 58, ABSORPTION OF ORAL SUPPLEMENTS INDLUDING STEROIDS, NUTRIENTS, AND REPLACEMENT MEDS MAY NOT OCCUR.

The Warning Signs

12/6/13 - After learning more about SARDS, the endocrine system, and animal nutrition I've come to the conclusion that we as a society are too willing to accept the first answer we get from a doctor. What people need to realize is that not every doctor specializes in a certain area, not every doctor has the same understanding as every other doctor and not all doctors treat their patients the same way. I feel this way about human medicinal practice as well as the field of veterinarians. We need to realize that there are still new discoveries being made and it takes a long time for word to get out to other doctors and to share these new discoveries. Also, there is a part of mainstream medicine that will not listen or accept any theories that are not based on double blind studies. This is a huge problem and plays a huge part in why we still see people and animals dying of diseases that have been around forever. We as a society are to ready to go with the norm and follow mainstream society's way of thinking. I think that it is our own responsibility to educate ourselves and not put our entire faith in the hands of someone else. If that were the case many more dogs would be sent home to die with SARDS that progressed into something worse like cancer. If you or your child suddenly went blind and your doctor told you it was just something that happened and you would adapt, what would you do? To me, this is an outrageous answer. I wanted to tell the general vet, the ophthalmalogist and the internist that they'd better go back to school and figure it out. Because neither people nor dogs go blind for no reason. So, let's start with the warning signs. The warning signs were that Shasta started to become heat intolerant. It was hard to tell because she is a snow dog living in Sacramento in the summer. She began drinking a lot of water and she had an insatiable appetite. She also started to potty in the house which is not normal behavior for her as she was only 5 yrs old. Other signs that I thought were normal issues with dogs was her sensitive stomach, scratching even though she had no fleas or rash, and shedding. Many people think that is normal for dogs as well, but I no longer think that. High estrogen causes a histamine effect in some dogs which causes them to scratch a lot. A sensitive stomach is common in dogs these days, but shouldn't be left untreated as it is a sign that something else is going on.

Back on Track

11/2/13 - I have changed Shasta's diet and am now feeding her a commercial Raw Food diet. I started with Small Batch beef patties, but there are too many foods high in phytoestrogens so I have switched to Chewy and Stella's Raw Foods. Shasta loves this food... it does contain foods that have phytoestrogens, but not nearly as high as others. After much research I'm unable to find a nutritious commercial dog food that does not include some phytoestrogens. Shasta digests this food well and her stomach seems to tolerate it as well, meaning she is absorbing the minerals and nutrients. It is expensive, but considering I'm not cooking her steaks anymore I think it evens out for right now. Once I get her back to normal weight I will cut back on the amounts I'm feeding her and that will cut the cost as well. : ) If you're nervous about a raw food diet, please do some research as it is much easier for animals to digest, easy to feed to your pets because they come in patties, and as long as you wash your hands and handle the raw meat as you would do any raw meats in your kitchen, it is safe. Since this diet change her stools have improved (much smaller and firmer), she is slowly gaining her weight back, and her coat is much softer. And she still is no longer shedding. I'm waiting to see if this changes as we come into winter, but it is truly unbelievable because we have always had lint rollers all over and had to constantly vaccum our cars, pillows and bedding.

A Bump in the Road

9/30/13 - Have you ever caught your dog eating her own stool or another dog's stool?? this is appalling especially when you spend so much money on good dog food or time and money making your pet's meals...but this is something they will do when they have an enzyme deficiency. Here is more information and a better explanation as to why dog's do this: http://drplechner.com/learn/miscellaneous-articles/digestive-enzymes/ Shasta did this on our walk the other day and although I was disgusted I knew I was going to run into some digestive problems...but didn't realize how far this would set her back. She kept doing it despite my efforts to pick up her poop immediately after she went potty and despite my efforts to make sure she didn't pick up anything on our walks. Shasta was not getting the nutrients she needed on the limited ingredients I was feeding her during this time that I was trying to weed out what she might be allergic too. She was also not absorbing the enzyme supplements that enables the breakdown of the food and therefore she was craving, starving, and not absorbing efficiently. She started to lose weight rapidly, her coat looked disheveled, and I could tell her vision and demeanor was worsening. I took her into to see my general vet and was scared to death when I saw how much weight she had lost. I had some blood work done and her results showed that her white blood cell count was high. My vet was concerned about her diet and wanted to prescribe antibiotics as long as Dr. P agreed it wouldn't disrupt his protocol. After consulting with Dr. P. we put Shasta on an antibiotic for 2 weeks and I started researching commercial dog foods again to get her on something more nutritious. At first I was reluctant to put her on a raw food diet because of her suppressed immune system, but further research indicated to me this was the best (but most expensive) choice. Within a week Shasta showed phenomenal results. She put on weight, her demeanor was better, her vision was better, she was no longer eating stool, she no longer had diarrhea and her coat was thick and shiny! : ) We are back on track. I have to say that since Shasta has started Dr. Plechner's treatment for her high estrogen and changing her diet, she has not been itching at all and she is no longer shedding like she used. We have always needed multiple lint rollers in the house, constantly vaccuming and washing bedding to keep the hair under control and now we have no need for any of it! : )

Real Improvement

9/23/13 - Shasta had a visit to the Ophthalmalogist today and the results were better than expected. The doctor actually said that it seemed like Shasta has some slight vision, which I was surprised because her initial exam showed she had no vision at all other than light transition and maybe shadows. Although I can tell that Shasta's left eye is worse than her right eye the test results compared to her initial visit a month ago, Shasta's right eye showed slight menace and slight dazzle and still has pupil dilation in both eyes. In layman terms when something comes close to her right eye she shows a natural reflex to blink or move away. Eye dazzle reflex is the involuntary avoidance response to light shined into the eye. She did not have either reflex shen she was diagnosed. Also, the doctor said that she has more retinal degeneration in the left eye than the right eye, but the doctor was surprised her right eye had not deteriorated much at all. She recommended some supplements to protect the eye cells Octiva and I-caps. I took Shasta on a walk this evening and she stopped and stared at a trash can. This reminded me of when I walk her around our block when she was a puppy and she would see the Halloween decorations and could not distinguish between a real person and an ornament and it would freak her out. Hopefully we are on the right track.

2nd Set of Lab Results

9/17/13 - Shasta's labs came back and her IgA is up to 60 so the meds are working and she doesn't need another injection. Dr. P. said to just increase her dose of Medrol. Her estrogen has decreased, but Dr. P. feels there is something she is eating that is not agreeing with her and preventing her from fully absorbing her meds and nutrients so the increased dose isn't going to hurt her it will only help her. This will also help to increase her T3 and T4 (thyroid levels). I'm keeping her on the beef and white rice this week to see how she does. She had a good weekend visiting with her gramma and grampa...she went to their house for the first time since losing her vision and she could tell when we got near their neighborhood and darted out of the car and up to their front door without any trouble. When we walked inside she smelled around and found her way to the water bowl and then of course her auntie Bridgette's toy box (Bridge is my parents' chihuahua). She went through the toys like she always does, found the ones that make noise, strewn them all over the house and sat and squeaked them loudly while grampa tried to watch the football game. : ) She came shopping with us during the day and then she had a walk at night. She did really well all weekend. No signs of improved vision yet, just better navigational skills. She will still bump into things up close especially in less familiar areas and in transition lighting. I decided to get her some Doggles to help protect her eyes. To clarify my findings with Shasta's overall improvement: Shasta's vision comes and goes and is often visible to me when it is worse when her eyes get a little more glowy or foggy looking. She is happier when she seems to have a little bit of vision, but she seems to be able to see things in the distance and not so much up close. She also seems to do better in bright lighting or sunlight and does worse in transitional lighting where there are a lot of shadows.

The Ups and Downs

9/11/13 - Shasta had a decent week overall. I had another blood panel done and sent off to NVDS to see if her IgA levels are above 58. If they are then I can continue with the oral meds, but need to figure out her food allergies although lately everything seems fine. I had held off on Shasta's eye supplements until we can be sure she is absorbing properly. I'm awaiting her lab results to see what's what. I could be off to L.A. this weekend for another shot if her IgA level is still below 58. I may get her some goggles or the chest harness with a halo because although Shasta has more good days than bad ones, I will be devastated to another degree if she pokes an eye out or even damages her eyes further. I have to say that there are still some short bouts of depression that I see Shasta go through. Some mornings she wakes up banging into everything and gets lost in my closet. Other days she gets around just fine, trots through the back door, hops up on the couch, greets her dad at the door, etc. Other times she sits there and I picture her wondering, "how much fun is being blind gonna be? this sucks." But just as I started feeling depressed the other day I was making her dinner and I suddenly felt this pinch on the back of my shorts, and then suddenly felt two huge paws on my back and she was pulling me by shirt to either wrestle with her or take her somewhere. I was so happy she was acting excited like that so I took her for a car ride and walk after dinner. On these good days I think she can see a little. As we get close to the side walk she will reach her paw up like she knew it was coming. She will also get out of the way for trees when we are walking. Then other times...bang! she will not see it coming at all.

A Discovery with Heartworm Preventatives and Pest Repellants

9/4/13 - Upon returning from the beach I realized it was time for Shasta's monthly dose of Heart Worm and Flea/Tick prevention medicine. What did the Ophtho say about an ingredient in heart worm prevention meds that can cause blindness? oh yeah...Ivermectin. So I have my daily discussion with Dr. P. and ask him about this and coincidentally he was working with another client and finding that some of these preventative meds for pets may be more significant in their role of blindness in dogs than originally had thought, along with other illnesses. So we both start digging deeper. Dr. P. went through some old case files and found out that even more recently a lot of cats have been experiencing heart attacks, strokes, and even death and the only thing found in their system as to a possible culprit are ingredients in these preventative meds. So we did some research and found some more case studies on these ingredients and I've decided to not give Shasta preventative heart worm or flea/tick meds for now. Dr. P and I have written an article for Nutricula Magazine regarding our findings of these studies, so if you are interested, please refer to Dr. P's website and/or Nutricula Magazine (online) where the article is published. http://www.nutriculamagazine.com/chemical-insect-repellents/